Lactosylated polymers for tissue engineering : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Chemistry at Massey University
dc.contributor.author | Shi, Zheng | |
dc.date.accessioned | 2018-02-15T01:52:11Z | |
dc.date.available | 2018-02-15T01:52:11Z | |
dc.date.issued | 2006 | |
dc.identifier.uri | http://hdl.handle.net/10179/12768 | |
dc.description.abstract | This thesis describes the synthesis of new polymers suitable for the support of in vitro hepatocyte growth. The key design feature of the monomers investigated was the incorporation of a galactose residue, expected to promote the adhesion and proliferation of hepatocytes in vitro, through the regioselective derivation of lactose. A graft polymerisation strategy was investigated as an alternative to co-polymerization, since it proved difficult to isolate the carbohydrate-derived monomers in sufficient purity. This led to the formation of a glutaraldehyde-crosslinked lactosylated polyamine hydrogel, which was found to perform well in initial cell trials. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Massey University | en_US |
dc.rights | The Author | en_US |
dc.subject | Biopolymers | en_US |
dc.subject | Tissue engineering | en_US |
dc.title | Lactosylated polymers for tissue engineering : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Chemistry at Massey University | en_US |
dc.type | Thesis | en_US |
thesis.degree.discipline | Chemistry | en_US |
thesis.degree.grantor | Massey University | en_US |
thesis.degree.level | Masters | en_US |
thesis.degree.name | Master of Science (M. Sc.) | en_US |