dc.contributor.author | Fitzsimons H | |
dc.contributor.author | Palmer MJ | |
dc.coverage.spatial | United States | |
dc.date.available | 2023 | |
dc.date.available | 2023-01-20 | |
dc.date.issued | 2023-01-30 | |
dc.identifier | https://www.ncbi.nlm.nih.gov/pubmed/36798589 | |
dc.identifier.citation | MicroPubl Biol, 2023, 2023 | |
dc.description | Copyright: © 2023 by the authors. | |
dc.description.abstract | Herzog (Hzg, CG5830) shares similarity to members of the haloacid dehalogenase subfamily of small CTD phosphatases. In Drosophila it is a maternal gene essential for establishment of embryonic segment polarity, and oligomerization is required for activation of phosphatase activity. While Hzg is expressed in the brain, its role has not been investigated. To that end, we further characterized Hzg expression in the brain and found that it is highly expressed in neurons of the mushroom body where it localises to axons, and is also expressed in cortical glia. We investigated its role in mushroom body development as well as courtship learning and memory, but found that knockdown of Hzg had no impact on these processes. In contrast, knockdown in post-mitotic neurons in the eye resulted in disruption to ommatidial patterning and pigmentation, indicating it plays an important role in eye development. | |
dc.language | eng | |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons
Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited. | |
dc.title | Herzog is not required for mushroom body development or courtship learning & memory but is required for eye development in Drosophila melanogaster | |
dc.type | Journal article | |
dc.citation.volume | 2023 | |
dc.identifier.doi | 10.17912/micropub.biology.000720 | |
dc.identifier.elements-id | 459757 | |
dc.relation.isPartOf | MicroPubl Biol | |
dc.identifier.eissn | 2578-9430 | |
dc.description.publication-status | Published online | |
pubs.organisational-group | /Massey University | |
pubs.organisational-group | /Massey University/College of Sciences | |
pubs.organisational-group | /Massey University/College of Sciences/School of Natural Sciences | |
dc.identifier.harvested | Massey_Dark | |
pubs.notes | Not known | |